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DataJobWebsite.jpg' alt='Job Portal Project Ppt' title='Job Portal Project Ppt' />Job Search by Indeed. Search millions of jobs from thousands of job boards, newspapers, classifieds and company websites on indeed. At SAP, we want to make the job application process as easy as possible for you. Learn all about setting up job alerts, interviewing, onboarding, and more. Thank you for your interest in HOCHTIEF Our employees are the basis of our successwith their engagement, professional knowhow and competencies as key. Job Portal Project Ppt' title='Job Portal Project Ppt' />PPT PLANTFACILITIES ENGINEERING IN THE PHARMACEUTICAL INDUSTRY Power. Point presentation free to view. Title PLANTFACILITIES ENGINEERING IN THE PHARMACEUTICAL INDUSTRY 1. PLANTFACILITIES ENGINEERING IN THE PHARMACEUTICAL INDUSTRY 2. FUNCTIONS OF THE PLANT ENGINEERING DEPTDesign and construction of facilities and systems Maintenance of facilities and systems Operation of system Environmental, Health safety Regulatory compliance Energy management Technology Validation Administration, supervision, organization, planning 3. DESIGN OF FACILITIESNEW PHARMACEUTICAL PROJECTFUNCTIONENGINEERING PROCUREMENT CONSTRUCTION COMMISSIONING START UP VALIDATION 4. PROJECT PHASESConceptual Long range plan development 1 5 years in advance Planning Project scope development for next year 6 1. Request for capital expenditures RCE Develop RCE documentation 2 4 months in advance Execution Immediately pre post funding Closeout Upon completion 5. TYPES OF PROJECTNew water for injection system Chilled water upgrade Clean rooms upgrade Installation of a second bag printer Optimize clave cycles Install thermal oxidizers Electrical bussway upgrade Upgrade hot stamp system Overhaul blow mold deflasher 6. PROJECT INDICATORSDid you meet project scope Did you meet project timeline Did the project was within budgetPREVENTIVE MAINTENANCENew equipment or changes are added to PM program via VCR validation change request Master PM describes Equipment identification Frequency Tasks to be performed Master PM approved by Maintenance coordinator, Engineering manager, Production manager, and Quality manager. PREVENTIVE MAINTENANCE REQUIREMENTSTasks and frequency determined by Manufacturers recommendation Historical data Department supervisor and maintenance coordinator verifies completion of PM tasks PM records maintained by the engineering department 9. SHUTDOWNInclude routine activity and projects Require project management tools Involve all department and contractors Training is critical to avoid safety issues Require maintenance resource availability 1. SPARE PARTSIncreased focus on better utilization of our stockroom dollars Plants are making progress in reducing the cost and number of spare parts in inventory Alternate suppliers are being identified to reduce the cost of parts In house local machine shops are being utilized where possible to fabricate parts for less than OEM cost 1. DOWNTIME ANALYSISSample report 1. Torch Browser Free Download For Pc Full Version. AUTONOMOUS MAINTENANCELine Operator Example 1. SWAT TEAMS PROCESS IMPROVEMENTSSWAT teams are used in some form at all sites Involves Six Sigma, Cost Reduction teams and Maintenance Productivity teams Team Targets Lines based on Labor Performance, Material Performance, and Standard Units Produced Line Improvement Projects are selected based on Cost vs. Return just like RCE projects Team evaluates mechanical performance, processes and procedures Team tracks effectiveness and strives to make permanent fixes 1. Define Problem Problem Statement Pareto Charts. DMAIC Process. Form Team Charter. Monitor Process Management Plan Control Charts. Scope Project SIPOC Map. Align wCustomer VOC Affinity Diagram. Train. Standardize Jurans Pyramid Flow Charting. What Data Five Points of View. Define. Control. Remedial Journey. How to Measure Operational Defs Measurements System Analysis. Anticipate Failure Mode Process FMEAWhich Units Representative Samples Contextual DataImplementAddress Human Side Leadership Tools. Diagnostic Journey. Measure. Plot Data Time Plots Control Charts Frequency Plots Histo ParetoImprove. Plan Implementation Planning Tools. Estimate Sigma. AnalyzeCreateMap Process Activity Flowchart Deployment Flowchart. Anticipate Failure Mode Design FMEAChoose Solution Priority Matrix Pugh Matrix. Focused Prob. Statement Problem SpecificationSet Criteria Multi Voting. List Probable Causes Is vs. Is Not FishboneFault Tree WhyDevelop Solutions Brainstorming Idea Box, etc. Implementation Problem. Test Verify Causes Scatter Diagram Strat Freq. Plots Tables. Decision Problem. Analyze Map Cycle Times Wastes. MANAGEMENT STANDARDSEHS Global Management Strategic Planning Self Assessment Risk Assessment Business Integration Training and Awareness Communication and Information Performance Measures Assurance Review 1. TECHNICAL STANDARDSConfined Spaces Entry Underground Storage Tanks Dangerous Goods Hazardous Material Waste Facility Selection Machine Guarding Spill Prevention Hazardous Process Waste Management Ergonomics Water 1. TECHNICAL STANDARDScontinuedEmergency Preparedness Planning Air Emissions Significant EHS Incident Reporting Contractor EHS Management Reproductive Hazard Management Chemical Hazard Communication Capital Project Review Occupational Health Services 1. REGULATORY AUDITSThe Audit criteria includes Federal Local Environmental, Health and Safety Regulations, Good manufacturing practices Audit approach Facility tour Inspections Employee interviews Documentation records Site programs and procedures System design 1. ENERGY SAVING INITIATIVESSteam natural gas Steam trap maintenance Pipes and valves insulation More efficient equipment Steam pressure adjustment Sanitation frequency Boiler economizer Electricity High efficiency motors Equipement operation schedules Low consumption fluorescent lamps Repair of compressed air leaks 2. Preliminary Data 2. PROCESS ENGINEERINGLyophilization Equipment Engineering Solution Preparation and Delivery System Engineering Pharmaceutical Water Systems Engineering CIP clean in place Systems Engineering SIP steam in place Systems Engineering Utility Systems Engineering Automation Engineering Design Filtration Selection Qualification Support   2. STERILIZATION ENGINEERINGTerminal Sterilization of Final Product Steam, Gamma, ETO Sterilization of Commodities Steam, Dry Heat, Gamma, ETO Sterilization of Aseptic Filling Equipment Steam, VHP, Dry Heat Sterilization Cycle Development Sterilizer Equipment Design Sterilizer TrayRack Design New Product Submission Generation and Support 2. PAT Systems for analysis and control of manufacturing processes based on timely measurements of critical quality parameters and performance attributes of raw materials and in process products, to assure end product quality at the completion of the process 2. PAT OBJECTIVESProduce The right quality In the shortest time At the lowest cost Predictable fashion Pharmaceutical Manufacturing Does not always meet all criteria Efficiency is lower than comparable industries Lots of room for improvement but improvement was almost discouraged 2. PAT TECHNOLOGIESSimple sensors p. H, temperature, pressure, etc Spectroscopic Near IR, Imagers, Mid IR, Raman, UV Vis, etc Physical properties Particle size and shape, thermal effusivity, acoustics, etc Classical analytical techniques HPLC, GC, LOD, etc 2. Hoover Breathe Easy Vacuum Manual there. VALIDATION LIFE CYCLE 2. VALIDATION IN THE FUTUREShift to continuous validation concepts from up front 3 batch concept this comes with PAT Increased usage of Commissioning activities and documentation to reduce IQOQ activities Focus validation efforts on product quality attributes Increased usage of documented Risk Assessments to streamline the validation testing 2.